These Saints lived during the years of Diocletian. Saint Cyrus was from Alexandria, and Saint John was from Edessa of Mesopotamia. Because of the persecution of that time, Cyrus fled to the Gulf of Arabia, where there was a small community of monks. John, who was a soldier, heard of Cyrus' fame and came to join him. Henceforth, they passed their life working every virtue, and healing every illness and disease freely by the grace of Christ; hence their title of "Unmercenaries." They heard that a certain woman, named Athanasia, had been apprehended together with her three daughters, Theodora, Theoctiste, and Eudoxia, and taken to the tribunal for their confession of the Faith. Fearing lest the tender young maidens be terrified by the torments and renounce Christ, they went to strengthen them in their contest in martyrdom; therefore they too were seized. After Cyrus and John and those sacred women had been greatly tormented, all were beheaded in the year 292. Their tomb became a renowned shrine in Egypt, and a place of universal pilgrimage. It was found in the area of the modern day resort near Alexandria named Abu Kyr.
Apolytikion in the Plagal of the Fourth Tone
Since Thou hast given us the miracles of Thy holy Martyrs as an invincible battlement, by their entreaties scatter the counsels of the heathen, O Christ our God, and strenghten the faith of Orthodox Christians, since Thou alone art good and the Friend of man.
Kontakion in the Plagal of the Second Tone
With a great voice, O ye faithful, let us hymn the great physicians of the world, the pair beloved of Christ, the luminaries who are radiant with the beams of healing; and as we stand in their temple, we cry out: Cyrus and John, the bestowers of miracles and healers of the ailing, shine forth to the ends of the world.